Nanostructured Polymer Scaffolds for Supporting Bone Regeneration

LIDER XIV Project (No. 0176/2023) Funded by The National Centre for Research and Development

Principal investigator

Dr. Łukasz Szymański

Principal Investigator of the Nanostructured Polymer Scaffolds for Supporting Bone Regeneration project, is a researcher with a prolific scientific portfolio, including numerous impactful publications in cancer biology, immunology, and medical device biocompatibility. With a specialization in immunology and cancer, Dr. Szymański has significantly advanced understanding in these fields, contributing to both fundamental and applied biomedical research. His achievements extend to pioneering work in medical device development, where he successfully led projects that brought two class III devices, 4Seal Hemostat and NE'X Surgical Adhesive, to market. As an expert in international standards, Dr. Szymański serves on key regulatory bodies, including the OECD’s immunotoxicity group, the US AAMI Biological Evaluation Committee, and Poland’s Technical Committee for Medical Materials and Biomaterials. His work integrates deep scientific knowledge with regulatory expertise, underscoring his commitment to advancing healthcare solutions through rigorous research and innovation

 

Project Overview:

Bone union is a vital and intricate process, aimed at restoring bone continuity and strength after injury. This biological healing process relies on a complex interaction between cellular elements and molecular factors, thriving in a supportive environment. Optimal bone healing conditions are crucial to ensuring rapid and effective tissue regeneration, an expectation that is increasingly important for patients who seek minimal disruption to their professional and daily lives.

The goal of this project is to create an innovative bioimplant that actively promotes bone healing at the cellular level, reducing the risk of complications such as delayed union or non-union. The proposed solution is a biodegradable scaffold, crafted from polymer nanofibers using advanced electrospinning techniques. These nanofibers are designed to release bioactive compounds directly into the fracture site, enhancing the regrowth process and supporting the formation of new bone tissue.

This bioimplant will be injectable, allowing it to conform precisely to fractures of any shape or complexity, ensuring complete and effective support across the injury site. The project’s outcome will be a preclinical, ready-for-testing bone substitute, designed to address a wide range of skeletal diseases and injuries with significant socio-economic benefits. Once complete, the bioimplant will offer a pioneering solution in bone regeneration therapy, streamlining the healing process and enabling patients to return to normal activities faster.

 

Media coverage:

https://naukawpolsce.pl/aktualnosci/news,100394,biomaterial-w-strzykawce-moze-przyspieszyc-zrastanie-kosci.html

https://dentonet.pl/biomaterial-w-strzykawce-moze-przyspieszyc-zrastanie-kosci/#gref