Resveratrol is a stilbenoid naturally synthesized by plants in response to stress or infection. This chemical is abundant in the skins of red grapes, and therefore in red wine. Resveratrol has attracted attention in the last two decades for its many purported health-promoting benefits in humans, especially anti-cancer or chemopreventive. However, its exact mechanisms and bioavailability are still unknown. Scientists from the Institute of Genetics and Animal Breeding of the Polish Academy of Sciences in Jastrzebiec suggest that the modern techniques of functional genomics and follow-up bioinformatic analyses can help elucidate the details of resveratrol’s actions. The group from Jastrzebiec have just published an article in the prestigious journal Biotechnology Advances on this topic. In a key result, the article identified a number of common cellular pathways affected by resveratrol in diverse types of cancer cells. In a follow up to this work‚ scientists from Jastrzebiec will conduct meta-analyses of the datasets available for anti-cancer and chemopreventive natural products such as revestratol and curcumin.
HUMINIECKI L, HORBAŃCZUK J., 2018 - The functional genomic studies of resveratrol in respect to its anti-cancer effects. Biotechnology Advances, doi: 10.1016/j.biotechadv.2018.02.011, IF=10.7